Syncronis C18

Syncronis C8

Syncronis AQ

Syncronis AQ

Syncronis C18

Syncronis C8

Syncronis AQ

Thermo Scientific Accucore RP-MS

Thermo Scientific Accucore C18

Accucore C8

Accucore Polar Premium

Thermo Scientific Accucore
Phenyl-Hexyl

Accucore Phenyl-X

Thermo Scientific Accucore PFP

Accucore C30

Thermo Scientific Accucore HILIC

Accucore Urea-HILIC

Accucore XL C18 & C8

Acclaim 120 C18

High performance reversed-phase columns for
reproducible results

• High hydrophobic retention

• Excellent efficiencies for maximum resolution

• Low silanol activity for excellent peak shapes for basic analytes

• Extremely low bleed, fully compatible with MS

Acclaim 120 C8

High performance reversed-phase columns with intermediate hydrophobic retention

• High hydrophobic retention

• Excellent efficiencies for maximum resolution

• Low silanol activity for excellent peak shapes for basic analytes

• Extremely low bleed, fully compatible with MS

Acclaim Phenyl-1

A unique reversed-phase column with high aromatic selectivity

• High aromatic selectivity

• High hydrophobic retention

• Unique and complementary selectivity compared to any other phenyl type column

• Compatibility with highly aqueous mobile phase

• High efficiency and rugged packing

Acclaim C30

Columns for separating structurally related isomers

• High shape selectivity

• Unique selectivity complementary to other reversed-phase columns

• High-quality: low column bleed, high efficiency and rugged packing The Acclaim C30 is designed to provide high shape selectivity for separating hydrophobic structural related isomers and unique selectivity complementary to other reversed-phase columns (e.g. C18)

Acclaim PolarAdvantage

Novel polar-embedded reversed-phase columns with unique selectivity

• Selectivity complementary to the C18 column

• Low silanol activity for excellent peak shape with basic compounds

• Compatible with 100% aqueous mobile phase

• High selectivity for hydrophobic aromatic molecules

• Wide range of applications

Acclaim PolarAdvantage II

Complementary selectivity and enhanced hydrolytic stability

• Unique selectivity complementary to the C18 column

• Novel polar-embedded column chemistry for hydrolytic stability

• Compatible with 100% aqueous mobile phase

• Low bleed for MS compatibility

• Wide range of applications

Acclaim HILIC-10

Designed with unique selectivity for hydrophilic molecules

• Retains highly polar molecules that are not retained by reversed-phase chromatography

• Unique selectivity, complementary to reversed-phase columns

• Hydrolytically stable

• Rugged column packing

• Broad application range

Acclaim Mixed-Mode HILIC-1

Uniquely designed for both reversed-phase and HILIC operations

• Can operate in both RP and HILIC modes

• Retains highly polar molecules

• Unique selectivity complementary to RP columns

• Broader application range compared with conventional diol-based columns

• High-efficiency column for high-resolution separations

OmniPac

DVB polymer columns for combined ion exchange and reversedphase separations

• Acid, base and solvent compatible, pH 0 to 14

• Ideal for the separation of high molecular weight organic acids

• Delivers optimal separation of very hydrophobic anions

• Delivers optimal separation of halogenated anions

• Provides simultaneous separation of neutral and ionic species

• Unique selectivity for polar and ionic organic analytes

• Delivers optimal separation of organic, hydrophobic, and halogenated cations

Acclaim Size Exclusion Chromatography (SEC)

High performance SEC columns for analysis of water soluble polymers

• Proprietary mono-dispersed multi-pore hydrophilic resin: no inflection points in calibration curve

• SEC-300 calibrated from 100 to 50,000 Daltons

• SEC-1000 calibrated from 1,000 to 1,000,000 Daltons

• Availability of small particle sizes packed in 300 x 4.6mm dimension allows for high-resolution analysis at reduced solvent consumption

• Stable surface bonding with low column bleed and compatibility with UV, RI, MS, ELSD and Thermo Scientific™ Dionex™ Corona™ Charged Aerosol Detectors

MAbPac Protein A

Fast mAb titer analysis

• High efficiency column

• Rugged, long column lifetime

• Excellent sample recovery

• Designed for ease of use and automation

AMAbPac SCX-10 RS

BioRS (Rapid Separation), strong cation exchange column designed for monoclonal antibodies and associated charged variants

• UHPLC, high throughput analysis

• Specially developed bio-inert PEEK lined stainless steel column hardware

• High pressure compatibility

MAbPac SEC-1

A size exclusion chromatography (SEC) column specifically designed for the high-resolution separation and characterization of monoclonal antibodies (mAbs) and their aggregates

• Analysis of monoclonal antibodies (mAbs) and their aggregates

• Analysis of mAb Fab and Fc fragments, even using high and low salt concentrations

• Hydrophilic bonded layer for minimal nondesired interactions between the biomolecules and the stationary phase

• Stable surface bonding leads to low column bleed and compatibility with MS, ELSD and Corona Charged Aerosol Detection (CAD)

pH Gradient Buffers

Ready-to-use buffers for simple method development during charge variant characterization The Thermo Scientific pH gradient platform accelerates method development and facilitates method transfer to QA/QC for a wide range of protein and mAb charge variants through a generic LCbased approach to charge variant characterization.

• Patented buffer formulations enable fast, robust and reproducible pH gradients that are simple to ptimize and easily automated

• Ready to use with existing LC columns and systems, without the need for time consuming mobile phase adjustments

• Applicable to the majority of mAbs

MAbPac SCX-10

Strong cation exchange column designed specifically for the highresolution, high efficiency charged variant analysis of monoclonal antibodies and associated variants

• Exceptionally high-resolution for monoclonal antibody charged variants separation

• Ideal for characterization and quality control assessment of monoclonal antibodies

• Unmatched column-to-column and lot-to-lot reproducibility

• Hydrophobic interactions greatly minimized

• Ideal for stability studies

• Meets the regulatory requirements for biopharmaceutical characterization

MAbPac HIC Family

Ready-to-use buffers for simple method development during charge variant characterization The Thermo Scientific pH gradient platform accelerates method development and facilitates method transfer to QA/QC for a wide range of protein and mAb charge variants through a generic LCbased approach to charge variant characterization.

• Advanced column chemistry designed for separating mAbs and related biologics

• Broad selectivity coverage formost challenging separations ofmAbs

• Excellent bio-compatibility

• High column efficiency

• Rugged column packing

MAbPac RP

High resolution accurate mass determination of monoclonal antibody variants, antibody drug conjugates (ADC) and proteins

• Superior resolution power for monoclonal antibodies and related substances

• High efficiency with low carry-over

• Excellent MS compatibility

• Wide operating pH range: 0 – 14

• High temperature stability: up to 110°C

• High throughput

ProPac WCX-10 and SCX-10

Weak and strong cation exchange columns with exceptionally high resolution and efficiency for separations of protein variants

• Characterization and quality control assessment of monoclonal antibodies and other proteins

• Exceptionally high-resolution and high-efficiency separations

• Useful for characterization of related protein variants including deamidation and mAb lysine truncation variants

• ProPac WCX-10 contains carboxylate functional groups and ProPac SCX-10 contains sulfonate functional groups

Accucore 150-Amide-HILIC

HPLC column for neutral glycan analysis

ProPac SCX-20

Strong cation-exchange column for high-resolution protein separations

• Graftedcation-exchangesurfaceprovidespH-basedselectivitycontrol

• Fast mass transfer for high-efficiency separation

GlycanPac AXH-1

High-resolution columns for neutral and charged glycan analysis

• Unique glycan selectivity based on charge, size and polarity

• Excellent resolution for both native and labeled glycans

• Useful for both high-resolution glycan profile characterization and easy quantification of glycans based on charge, size and polarity

• Compatible with fluorescence and MS detection methods

• High chromatographic efficiency and excellent column stability

ProPac WAX-10 and SAX-10

Weak and strong anion anion-exchange providing unequalled high resolution and efficiency in the separations of protein variants

• High-efficiency, high-resolution separations

• Useful for characterization and quality control assessment of closely-related protein variants

• Supports separation of proteins that differ by as little as one amino acid residue

• Neutral hydrophilic coat that eliminates protein-resin hydrophobic interactions

• Superior lot-to-lot and column-to-column reproducibility

• ProPac WAX-10 column contains a tertiary amine functional group and ProPac SAX-10 contains a quaternary amine functional group

GlycanPac AXR-1

GlycanPac AXR-1 Ultra-high resolution columns for neutral, chargedand glycan isomer analysis

• Excellent glycan selectivity based on hydrophobicity, charge, size and isomerization

• High resolution for isomeric glycans

• Compatibility with fluorescence and MS detection methods

• High column efficiency and stability

• Ideal tool for qualitative, quantitative and structural analysis of glycans

ProPac PA1

For hydrophilic anionic protein separations

• Good for hydrophilic proteins and peptides

• Idealforhigh-resolutionseparationsofproteinswithpIvaluesfrom3to11

• Available in semipreparative format

• Pellicular packing ensures high-efficiency and fast mass transport

BioBasic AX

Optimized for the separation of proteins, peptides, other anionic species and polar molecules

• Weak anion exchange phase for multiple charged species

• 300Å pore size for enhanced protein and peptide separations

• Suitable for HILIC retention and separation of highly polar molecules

• Superb stability under demanding pH conditions

BioBasic 8

Optimized for the separation of a wide range of peptides

• C8 with 300Å pore size for improved biomolecule analysis

• An excellent starting column for protein and peptide analysis

• Outstanding reproducibility, efficiency and column lifetime

• Excellent for LC-MS separations

ProSwift IEX

Monolith IEX columns for high-resolution and fast protein analysis

• High resolution

• High loading capacity

• Fast analysis

• Wide range of operational flow rates

• Excellent stability over a wide pH range

• Outstanding reproducibility and ruggedness

BioBasic 4

• Based on 300Å silica for outstanding biomolecule performance

• C4 with lower carbon load for optimal retention of larger peptides and proteins

• Outstanding reproducibility, efficiency and column lifetime

• Excellent for LC-MS separations

BioBasic 18

Outstanding separation of small to medium peptides

• C18 with 300Å pore size for maximum performance with biomolecules

• High peak capacity stationary phase

• Outstanding reproducibility, efficiency and column lifetime

• Excellent for LC-MS separations

Acclaim 300 C18

High-resolution reversed-phase separation of proteins and peptides

• Designed for high-resolution peptide mapping and protein separations

• Application tested for suitability in peptide mapping

• Reproducible for dependable results

• LC-MS compatible

• Ultrapure silica with low metal content and exhaustive bonding and endcapping

Accucore 150-C18

• Designed for the separation of peptides

• Outstanding resolution

• 150Å pore diameter material

BioBasic SEC

Superior separation of water soluble compounds

• Covers separation of analytes over a wide molecular weight range

• Long column life and high column efficiencies

• Simple mechanism of interaction based on molecular size and shape

• Ideal for sample clean-up

• Straightforward method development, simple mobile phases

Accucore 150-C4

• Significantly lower hydrophobic retention than C18

• Ideal for retention of proteins and larger peptides

DNAPac PA100

A strong anion exchange column developed to provide high-resolution analysis and purification of synthetic oligonucleotides

• High-resolution oligonucleotide separations

• Achieve n, n-1 resolution for oligonucleotides

• Resolves oligonucleotides with secondary structures

• Suitable for the analysis of phosphorothioate-based clinical samples

• Easy scale-up from 2.0mm to 22mm ID column (>100x)

ProSwift RP

Reversed-phase monolith columns that uniquely provide the advantages of high resolution at exceptionally high flow rates for fast protein separations and analysis

• High resolution at high speed

• Highest operational flow rates available

• High throughput and improved productivity

• Excellent stability over a wide pH range of 1 to 14

• Outstanding reproducibility and ruggedness

• High stringent wash compatible, for example, 1 M NaOH

• High loading capacity

DNAPac PA200

A strong anion exchange column developed to provide the best resolution for analysis and purification of synthetic oligonucleotides

• Achieve n, n-1 resolution for oligonucleotides

• Resolve oligonucleotides with secondary structures

• Resolves oligonucleotides with secondary structures

• Assay phosphorothioate purity

• Selectivity control with eluent pH, salt, and solvent

• Resolve RNA with aberrant (2’, 5’) links from normal ssRNA

• HR/AM AXLC/MS via automated desalting

ProPac HIC-10

Hydrophobic Interaction Chromatography columns for the high-resolution separation of proteins and peptides

• High-resolution HPLC separation of proteins, protein variants and peptides

• Proteins are separated under non-denaturing conditions

• High protein loading capacity for protein purification applications

• Wide range of applications

• Based on 5μm ultra high purity spherical silica gel particles with 300Å pores

DNAPac PA200 RS

UHPLC Solutions for nucleic acid analysis

• Provide single base resolution of oligonucleotides

• Higher efficiency to improve resolution

• Ruggedness consistent with the DNAPac PA200 column line

• Stable to 10,000 psi

DNASwift SAX-1S

A strong anion exchange monolith column that provides improved capacity and industry-leading oligonucleotide yield-purity performance.

• Micromole purifications in a 5mm ID column body

• Substantial capacity in a small format

• Tunable selectivity control, like the DNAPac columns, for high resolution

• Compatible with high pH mobile phases, solvents, or high temperatures

• Ideal for therapeutic and diagnostic oligonucleotide research Purify difficult oligonucleotide products

DNAPac RP

Reverse phase (RP) column specifically for analysis of oligonucleotides and double stranded (ds) DNA and RNA fragments.

• Excellent MS compatibility

• Wide operating pH range: 0–14

• High temperature stability: up to 110°C

• Stable to 10,000 psi

• High throughput